The Advanced Photon Source
a U.S. Department of Energy Office of Science User Facility

Studying Elements from the SARS-CoV-2 Virus at the Bio-CAT Beamline at the Advanced Photon Source

Small-angle solution x-ray scattering and biochemical characterization studies at the Bio-CAT beamline 18-ID at the APS are being used to study the structure of portions of RNA from the SARS-CoV-2 virus. This RNA contains the genetic instructions the virus uses to replicate itself. These experiments are designed to see how these structures change when they interact with selected small molecules that are potential drug candidates. This work is a collaboration between Blanton Tolbert (Department of Chemistry, Case Western Reserve University), Amanda Hargrove (Duke University) , Srinivas Chakravarthy (Illinois Institute of Technology, pictured here while wearing a face mask as required by Illinois’ COVID-19 prevention controls) and a nuclear magnetic resonance consortium coordinated by Harald Schwalbe at the Goethe University (Germany). NOTE: No live coronavirus is used in studies at the APS. 

The Advanced Photon Source is a U.S. DOE Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357.

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