The Advanced Photon Source
a U.S. Department of Energy Office of Science User Facility

To Your Health: Disease-Fighting Research at the APS

To better understand amorphous-amorphous phase separation that can reduce or even halt active drug release, researchers used high-brightness x-rays at the U.S. Department of Energy’s Advanced Photon Source, opening the way to some promising opportunities for the development and design of new and improved systems.

Moving technology forward with research at the Advanced Photon Source

Improved catalytic converters for the next generation of ultra-low-emission vehicles could result from an innovative approach demonstrated in research at the U.S. Department of Energy’s APS.

New knowledge from research at the Advanced Photon Source

Using microscale analysis of bird wings at the U.S. Department of Energy’s Advanced Photon Source, a team of researchers has discovered new insights into the mechanisms that give morphing wings their flight advantage.

Fighting Disease with Research at the Advanced Photon Source

X-rays from the U.S. Department of Energy’s Advanced Photon Source help researchers obtain crucial information for the development of therapies for Parkinson's disease.

Toward Better, Safer Materials with Research at the APS

To shed light on the mysterious, exact process by which cement transforms from a fresh paste into a solid, researchers utilized high-brightness x-rays with imaging methods at the U.S. Department of Energy’s Advanced Photon Source.

Another discovery by users of the APS

Methane, the simplest hydrocarbon molecule has extraordinary potential as a building block for a wide range of useful chemicals, from fuels to polymers. Research at the Advanced Photon Source revealed a promising strategy for getting more out of methane.

Moving technology forward with research at the Advanced Photon Source

Researchers used the U.S. Department of Energy's APS to study a promising class of thermoelectric materials with the goal of converting waste heat into electricity, or replacing mechanical cooling systems that rely on fossil fuels with more environmentally friendly solid-state devices.

To Your Health: Disease-Fighting Research at the APS

Researchers using high-brightness x-rays from the U.S. Department of Energy’s Advanced Photon Source obtained important data that furthered research into an anti-cancer compound that has shown “profound” activity in mouse models against two subtypes of leukemia — representing up to 40% of patients.

Moving technology forward with research at the Advanced Photon Source

High-speed phase contrast x-ray imaging of wave propagation in additive manufacturing-fabricated polymer lattice structures demonstrates interesting, unexpected classical mechanical phenomena in a novel AM structure and promises that a better understanding of the dynamic behavior of these unique materials is within reach.

Discovering the secrets of materials with the Advanced Photon Source

Researchers used the unique capabilities of the Advanced Photon Source to detail for the first time how copper, magnesium, or zinc change the nanoscale structure of aluminum, and to explore how we might control the metallurgy to design even better aluminum alloys with even more desirable properties.

Moving the boundaries of the possible with the Advanced Photon Source.

Researchers using the APS carried out the first proof-of-concept experiments using high-viscosity sample injection combined with pink-beam serial crystallography, offering a glimpse into the possibilities of molecular moving pictures.

Argonne Restricts User Facility Access for Non-Argonne Users

Argonne National Laboratory has made the decision to further reduce on-site activities and enter minimum safe operations mode. The APS will remain operational to support critical COVID-19 related work and for critical remote research only. We will lift restrictions as soon as it is safe to do so.

COVID-19 PORTAL. In light of the rapidly changing situation world-wide resulting from the COVID-19 virus, the Department of Energy Basic Energy Sciences light sources want to ensure they are doing everything possible to enable research into this virus and the search for an effective vaccine or other treatment. The DOE supports research into structural biology in partnership with the National Institutes of Health, and universities. This portal collects relevant structural biology resources in a single location, listing their basic characteristics and a point of contact for each.

Expedited, Rapid Access Call for COVID-19 Research

The APS continues to operate, providing expedited, remote access but only for research related to COVID-19 at this time. The Structural Biology Portal lists available APS beamlines for macromolecular crystallography and BioSAXS. Step-by-step instructions on how to apply for expedited beam time are listed on the New User Checklist. All users must be registered and their home institution must have an active User Agreement.

Please submit a Rapid Access proposal and state that the research is related to SARS CoV-2 proteins or COVID-19. The Experimental Safety Approval Form (ESAF) should also indicate SARS CoV-2 or COVID-19.

For administrative assistance, please contact the APS User Office at apsuser@aps.anl.gov. For technical assistance, please contact Bob Fischetti at rfischetti@anl.gov.

APS OPERATIONS SCHEDULE UPDATE:
To continue to meet the needs for ongoing, remote-only COVID-19 research, APS management will extend the current 2020-1 run by two weeks – to May 12. Please see more information and the revised long-range schedule here.

Updated 03/26/2020

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DOE Tackling the Challenge of Coronavirus

Thousands of processors stacked over six feet high are networked together into the fastest computer in the world. Powerful X-rays produced by accelerating electrons to near the speed of light. Computer software that can model the complex spread of diseases. These are just some of the tools that we here at the Department of Energy are using to tackle the COVID-19 disease outbreak, widely referred to as the coronavirus.

APS in the News

APS Coronavirus Research in the Media Spotlight

Information in the media about coronavirus (COVID-19) research at Argonne and the APS continues to mount.

Press Release

New Coronavirus Protein Reveals Drug Target

A potential drug target has been identified in a newly mapped protein of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). The structure was solved by a team including the University of Chicago, the U.S. Department of Energy’s Argonne National Laboratory, Northwestern University Feinberg School of Medicine and the University of California, Riverside School of Medicine.

APS/User News

Hsinhan (Dave) Tsai Earns the 2020 APSUO Rosalind Franklin Young Investigator Award

The Advanced Photon Source Users Organization is pleased to announce that Hsinhan (Dave) Tsai of Los Alamos National Laboratory is the recipient of the 2020 APSUO Rosalind Franklin Young Investigator Award for his "prolific record of high impact achievements, driving innovations in instrumental capabilities and fostering new collaborations."