The Advanced Photon Source
a U.S. Department of Energy Office of Science User Facility

SARS-CoV-2 Publications from Research at the Advanced Photon Source

March 30, 2020: “Structural basis of receptor recognition by SARS-CoV-2,” Jian Shang, Gang Ye, Ke Shi, Yushun Wan, Chuming Luo, Hideki Aihara, Qibin Geng, Ashley Auerbach, and Fang Li, Nature. DOI: 10.1038/s41586-020-2179-y / Northeastern Collaborative Access Team (NE-CAT) beamline 24-ID / The March 30, 2020, issue of the Guardian reported on the work.

April 3, 2020: “A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV,” Meng Yuan, Nicholas C. Wu, Xueyong Zhu, Chang-Chun D. Lee, Ray T. Y. So, Huibin Lv, Chris K. P. Mok, and Ian A. Wilson, Science. DOI: 10.1126/science.abb7269 / National Institute of General Medical Sciences and National Cancer Institute (GM/CA-XSD) beamline 23-ID-D

April 17, 2020: “Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2,” Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Mateusz Wilamowski, Michael Endres, Adam Godzik, Karolina Michalska, and Andrzej Joachimiak, Protein Science. DOI: 10.1002/pro.3873 / Structural Biology Center (SBC-XSD) beamline 19‐ID-D

May 5, 2020: “Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies,” Daniel Wrapp, Dorien De Vlieger, Kizzmekia S. Corbett, Gretel M. Torres, Nianshuang Wang, Wander Van Breedam, Kenny Roose, Loes van Schie, VIB-CMB COVID-19 Response Team, Markus Hoffmann, Stefan Pöhlmann, Barney S. Graham, Nico Callewaert, Bert Schepens, Xavier Saelens, and Jason S. McLellan, Cell.   DOI: 10.1016/j.cell.2020.04.031 / SBC-XSD beamline 19-ID-D

May 8, 2020: “A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV,” Meng Yuan, Nicholas C. Wu, Xueyong Zhu, Chang-Chun D. Lee, Ray T. Y. So, Huibin Lv, Chris K. P. Mok, and Ian A. Wilson, Science. DOI: 10.1126/science.abb7269 / GM/CA-XSD beamline 23-ID-D

June 17, 2020: “Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease,” Chunlong Ma, Michael Dominic Sacco, Brett Hurst, Julia Alma Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, Michael Thomas Marty, Yu Chen, and Jun Wang, Cell Research. DOI: 10.1038/s41422-020-0356-z / SBC-XSD beamline 19-ID-D

June 24, 2020: “Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3,” David N. Frick, Rajdeep S. Virdi, Nemanja Vuksanovic, Narayan Dahal, and Nicholas R. Silvaggi,  BiochemistryDOI: 10.1021/acs.biochem.0c00309 / Life Sciences CAT (LS-CAT) beamline 21-ID-F

July 12, 2020: “Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein,” Qiaozhen Ye, Alan M. V. West, Steve Silletti, and Kevin D Corbett, Protein Science. DOI: 10.1002/pro.3909 / NE-CAT beamline 24-ID‐E 

July 17, 2020: “Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes,” Karolina Michalska, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Lucy Stols, Michael Endres, and Andrzej Joachimiak, IUCrJ. DOI: 10.1107/S2052252520009653 / SBC-XSD beamline 19-ID-D

July 24, 2020: “Structural basis of RNA cap modification by SARS-CoV-2,” Thiruselvam Viswanathan, Shailee Arya, Siu-Hong Chan, Shan Qi, Nan Dai, Anurag Misra, Jun-Gyu Park, Fatai Oladunni, Dmytro Kovalskyy, Robert A. Hromas, Luis Martinez-Sobrido, and Yogesh K. Gupta, Nature Communications. DOI: 10.1038/s41467-020-17496-8 / NE-CAT beamline 24-ID-C

August 19, 2020: “3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice,” Athri D. Rathnayake, Jian Zheng, Yunjeong Kim, Krishani Dinali Perera3, Samantha Mackin, David K. Meyerholz, Maithri M. Kashipathy, Kevin P. Battaile, Scott Lovell, Stanley Perlman, William C. Groutas, and Kyeong-Ok Chang, Science Translational Medicine. DOI: 10.1126/scitranslmed.abc5332 / Industrial Macromolecular Crystallography Association CAT (IMCA-CAT) beamline 17-ID-B

September 29, 2020: “High-resolution structures of the SARS-CoV-2 2′-O-methyltransferase reveal strategies for structure-based inhibitor design,” Monica Rosas-Lemus, George Minasov, Ludmilla Shuvalova, Nicole L. Inniss, Olga Kiryukhina, Joseph Brunzelle, and Karla J. F. Satchell, Science Signaling. DOI: 10.1126/scisignal.abe1202 / LS-CAT beamline 21-ID-F

October 16, 2020: "Activity profiling and crystal structures of inhibitorbound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design," Wioletta Rut, Zongyang Lv, Mikolaj Zmudzinski, Stephanie Patchett, Digant Nayak, Scott J. Snipas, Farid El Oualid, Tony T. Huang, Miklos Bekes, Marcin Drag, and Shaun K. Olsen, Science Advances. DOI: 10.1126/sciadv.abd4596 NE-CAT 24-ID-C

November 2020: “Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy,” Ivan G. Shabalin, Mateusz P. Czub, Karolina A. Majorek, Dariusz Brzezinski, Marek Grabowski, David R. Cooper, Mateusz Panasiuk, Maksymilian Chruszcz, and Wladek Minor, IUCrJ. DOI: 10.1107/S2052252520012944 / LS- CAT 21-ID-F

 

Structural overlay of the SARS‐CoV‐2 N2b dimer (blue) and the equivalent domain of SARS‐CoV‐N (PDB ID 2CJR). From Q. Ye et al., Protein Science. DOI: 10.1002/pro.3909 © 2020 The Protein Society / NE-CAT beamline 24-ID‐E

Last Updated
10.19.2020