The Advanced Photon Source
a U.S. Department of Energy Office of Science User Facility

SARS-CoV-2 Publications, Preprints, Highlights, and Features about Research at the Advanced Photon Source

Publications

April 1: “Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors,” S. Iketani, F. Forouhar, H. Liu, S.J. Hong, F.Y. Lin, M.S. Nair, A. Zask, Y. Huang, L. Xing, B.R. Stockwell, A. Chavez, and D.D. Ho, Nature Communications DOI: 10.1038/s41467-021-22362-2 / NE-CAT 24-ID-E

March 2021: “Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite,” Gabriele Cerutti, Yicheng Guo, Tongqing Zhou, Jason Gorman, Myungjin Lee, Micah Rapp, Eswar R. Reddem, Jian Yu, Fabiana Bahna, Jude Bimela, Yaoxing Huang, Phinikoula S. Katsamba, Lihong Liu, Manoj S. Nair, Reda Rawi, Adam S. Olia, Pengfei Wang, Baoshan Zhang, Gwo-Yu huang, David D. Ho, Zizhang Sheng, Peter D. Kwong, and Lawrence Shapiro, “Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite,” Cell Host Microbe DOI: 10.1016/j.chom.2021.03.005 / NE-CAT 24-ID-C

February 22, 2021: “Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations,” C.H. Zhang, E.A. Stone, M. Deshmukh, J.A. Ippolito, M.M. Ghahremanpour, J. Tirado-Rives, K.A. Spasov, S. Zhang, Y. Takeo, S.N. Kudalkar, Z. Liang, F. Isaacs, B. Lindenbach, S.J. Miller, K.S. Anderson, and W.L. Jorgensen,  ACS Central Science DOI: 10.1021/acscentsci.1c00039 / NE-CAT 24-ID-C and 24-ID-E

February 9, 2021: "Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2", Youngchang Kim, Jacek Wower, Natalia Maltseva, Changsoo Chang, Robert Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad Nicolaescu, Glenn Randall, Karolina Michalska, and Andrzej Joachimiak, Commun. Biol. DOI: 10.1038/s42003-021-01735-9 / SBC-XSD 19-ID

February 2, 2021: “Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors,” Jerzy Osipiuk, Saara-Anne Azizi, Steve Dvorkin, Michael Endres, Robert Jedrzejczak, Krysten A. Jones, Soowon Kang, Rahul S. Kathayat, Youngchang Kim, Vladislav G. Lisnyak, Samantha L. Maki, Vlad Nicolaescu, Cooper A. Taylor, Christine Tesar, Yu-An Zhang, Zhiyao Zhou, Glenn Randall, Karolina Michalska, Scott A. Snyder, Bryan C. Dickinson, and Andrzej Joachimiak, Nature Communications. DOI: 10.1038/s41467-021-21060-3 / SBC-XSD 19-ID

January 12, 2021:  “Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape,” Paul-Albert König, Hrishikesh Das, Hejun Liu, Beate M. Kümmerer, Florian N. Gohr, Lea-Marie Jenster, Yonas M. Tesfamariam, Lisa D.J. Schiffelers, Miki Uchima, Jennifer D. Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H. Christensen, Caroline I. Fandrey,  Sabine Normann, Steffen Pritzl, Jan M. P. Tödtmann, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan Leo Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A. Wilson, Matthias Geyer, Kerstin U. Ludwig, B. Martin Hällberg, Nicholas C. Wu and Florian I. Schmidt, Science DOI: 10.1126/science.abe6230 / GM/CA-XSD 23-ID-B

December 9, 2020: "Structure and inhibition of the SARS-CoV-2 main protease reveals strategy for developing dual inhibitors against Mpro and cathepsin L", Michael Dominic Sacco, Chunlong Ma, Panagiotis Lagarias, Ang Gao, Julia Alma Townsend, Xiangzhi Meng, Peter Dube, Xiujun Zhang, Yanmei Hu, Naoya Kitamura, Brett Hurst, Bart Tarbet, Michael Thomas Marty, Antonios Kolocouris, Yan Xiang, Yu Chen, Jun Wang, Science Advances DOI: 10.1126/sciadv.abe0751 / SBC-XSD 19-ID-D

November 18, 2020: “Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site,” Jaeyong Lee, Liam J. Worrall, Marija Vuckovic, Federico I. Rosell, Francesco Gentile, Anh-Tien Ton, Nathanael A. Caveney, Fuqiang Ban, Artem Cherkasov, Mark Paetzel, and Natalie C. J. Strynadka, Nature Communications. DOI: 10.1038/s41467-020-19662-4 / GM/CA-XSD 23-ID-B.

November 5, 2020 "Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2", Yufei Xiang, Sham Nambulli, Zhengyun Xiao, Heng Liu, Zhe Sang, W. Paul Duprex, Dina Schneidman-Duhovny, Cheng Zhang, and Yi Shi, Science DOI: 10.1126/science.abe4747 / GMCA-XSD 23-ID-B

November 2020: “Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy,” Ivan G. Shabalin, Mateusz P. Czub, Karolina A. Majorek, Dariusz Brzezinski, Marek Grabowski, David R. Cooper, Mateusz Panasiuk, Maksymilian Chruszcz, and Wladek Minor, IUCrJ. DOI: 10.1107/S2052252520012944 / LS- CAT 21-ID-F

October 27, 2020: "Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation," Nicholas K. Hurlburt, Emilie Seydoux, Yu-Hsin Wan, Venkata Viswanadh Edara, Andrew B. Stuart, Junli Feng, Mehul S. Suthar, Andrew T. McGuire, Leonidas Stamatatos, and Marie Pancera, Nature Communications. DOI: 038/s41467-020-19231-9 / SBC-XSD 19-ID

October 27, 2020, “Structure of human steroid 5α-reductase 2 with anti-androgen drug finasteride” by Qingpin Xiao, Lei Wang, Shreyas Supekar, Tao Shen, Heng Liu, Fei Ye, Junzhou Huang, Hao Fan, Zhiyi Wei, and Cheng Zhang, Nature Communications. DOI: 10.21203/rs.3.rs-40159/v1 / GM/CA-XSD 23-ID-B

October 16, 2020: "Activity profiling and crystal structures of inhibitorbound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design," Wioletta Rut, Zongyang Lv, Mikolaj Zmudzinski, Stephanie Patchett, Digant Nayak, Scott J. Snipas, Farid El Oualid, Tony T. Huang, Miklos Bekes, Marcin Drag, and Shaun K. Olsen, Science Advances. DOI: 10.1126/sciadv.abd4596 / NE-CAT 24-ID-C

October 15, 2020: “Discovery of Ketone-Based Covalent Inhibitors of Coronavirus3CL Proteases for the Potential Therapeutic Treatment of COVID-19,” Robert L. Hoffman, Robert S. Kania, Mary A. Brothers, Jay F. Davies, Rose A. Ferre, Ketan S. Gajiwala, Mingying He, Robert J. Hogan, Kirk Kozminski, Lilian Y. Li, Jonathan W. Lockner, Jihong Lou, Michelle T. Marra, Lennert J. Mitchell Jr., Brion W. Murray, James A. Nieman, Stephen Noell, Simon P. Planken, Thomas Rowe, Kevin Ryan, George J. Smith III, James E. Solowiej, Claire M. Steppan, Barbara Taggart, J. Med. Chem. DOI: 10.1021/acs.jmedchem.0c01063 / IMCA-CAT 17-ID-B

September 29, 2020: “High-resolution structures of the SARS-CoV-2 2′-O-methyltransferase reveal strategies for structure-based inhibitor design,” Monica Rosas-Lemus, George Minasov, Ludmilla Shuvalova, Nicole L. Inniss, Olga Kiryukhina, Joseph Brunzelle, and Karla J. F. Satchell, Science Signaling. DOI: 10.1126/scisignal.abe1202 / LS-CAT 21-ID-F

August 19, 2020: “3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice,” Athri D. Rathnayake, Jian Zheng, Yunjeong Kim, Krishani Dinali Perera3, Samantha Mackin, David K. Meyerholz, Maithri M. Kashipathy, Kevin P. Battaile, Scott Lovell, Stanley Perlman, William C. Groutas, and Kyeong-Ok Chang, Science Translational Medicine. DOI: 10.1126/scitranslmed.abc5332 / IMCA-CAT 17-ID-B

July 24, 2020: “Structural basis of RNA cap modification by SARS-CoV-2,” Thiruselvam Viswanathan, Shailee Arya, Siu-Hong Chan, Shan Qi, Nan Dai, Anurag Misra, Jun-Gyu Park, Fatai Oladunni, Dmytro Kovalskyy, Robert A. Hromas, Luis Martinez-Sobrido, and Yogesh K. Gupta, Nature Communications. DOI: 10.1038/s41467-020-17496-8 / NE-CAT 24-ID-C

July 17, 2020: “Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes,” Karolina Michalska, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Lucy Stols, Michael Endres, and Andrzej Joachimiak, IUCrJ. DOI: 10.1107/S2052252520009653 / SBC-XSD 9-ID-D

July 12, 2020: “Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein,” Qiaozhen Ye, Alan M. V. West, Steve Silletti, and Kevin D Corbett, Protein Science. DOI: 10.1002/pro.3909 / NE-CAT 24-ID‐E 

June 24, 2020: “Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3,” David N. Frick, Rajdeep S. Virdi, Nemanja Vuksanovic, Narayan Dahal, and Nicholas R. Silvaggi,  BiochemistryDOI: 10.1021/acs.biochem.0c00309 / LS-CAT 21-ID-F

June 17, 2020: “Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease,” Chunlong Ma, Michael Dominic Sacco, Brett Hurst, Julia Alma Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, Michael Thomas Marty, Yu Chen, and Jun Wang, Cell Research. DOI: 10.1038/s41422-020-0356-z / SBC-XSD 19-ID-D

May 8, 2020: “A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV,” Meng Yuan, Nicholas C. Wu, Xueyong Zhu, Chang-Chun D. Lee, Ray T. Y. So, Huibin Lv, Chris K. P. Mok, and Ian A. Wilson, Science. DOI: 10.1126/science.abb7269 / GM/CA-XSD 23-ID-D

May 5, 2020: “Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies,” Daniel Wrapp, Dorien De Vlieger, Kizzmekia S. Corbett, Gretel M. Torres, Nianshuang Wang, Wander Van Breedam, Kenny Roose, Loes van Schie, VIB-CMB COVID-19 Response Team, Markus Hoffmann, Stefan Pöhlmann, Barney S. Graham, Nico Callewaert, Bert Schepens, Xavier Saelens, and Jason S. McLellan, Cell.   DOI: 10.1016/j.cell.2020.04.031 / SBC-XSD 19-ID-D

April 17, 2020: “Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2,” Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Mateusz Wilamowski, Michael Endres, Adam Godzik, Karolina Michalska, and Andrzej Joachimiak, Protein Science. DOI: 10.1002/pro.3873 / SBC-XSD 19‐ID-D

April 3, 2020: “A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV,” Meng Yuan, Nicholas C. Wu, Xueyong Zhu, Chang-Chun D. Lee, Ray T. Y. So, Huibin Lv, Chris K. P. Mok, and Ian A. Wilson, Science. DOI: 10.1126/science.abb7269 / GM/CA-XSD 23-ID-D

March 30, 2020: “Structural basis of receptor recognition by SARS-CoV-2,” Jian Shang, Gang Ye, Ke Shi, Yushun Wan, Chuming Luo, Hideki Aihara, Qibin Geng, Ashley Auerbach, and Fang Li, Nature. DOI: 10.1038/s41586-020-2179-y / NE-CAT 24-ID / The March 30, 2020, issue of the Guardian reported on the work.

Pre-Review Manuscripts

April 4, 2021: “Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoN,” N.H. Moeller, K. Shi, O. Demir, S. Banerjee, L. Yin, C. Belica, C. Durfee, R.E. Amaro, and H. Aihara, (2021) bioRXiv DOI: 10.1101/2021.04.02.438274 NE-CAT 24-ID-C

March 5, 2021: “Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2,” E. Tayeb-Fligelman, X. Cheng, C. Tai, J.T. Bowler, S. Griner, M.R. Sawaya, P.M. Seidler, Y.X. Jiang, J. Lu, G.M. Rosenberg, L. Salwinski, R. Abskharon, C.T. Zee, K. Hou, Y. Li, D.R. Boyer, K.A. Murray, G. Falcon,  D.H. Anderson, D. Cascio, L. Saelices, R. Damoiseaux, F. Guo, and D.S. Eisenberg, BioRXiv. DOI: 10.1101/2021.03.05.434000 / NE-CAT 24-ID-E

February 1, 2021: “Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2′-O-methyl transfer by SARS-CoV-2 nsp16,” George Minasov, Monica Rosas-Lemus, Ludmilla Shuvalova, Nicole L. Inniss, Joseph S. Brunzelle, Courtney M. Daczkowski, Paul Hoover, Andrew D. Mesecar, and Karla J. F. Satchell DOI: https://doi.org/10.1101/2021.01.31.429023 / LS-CAT 21-ID

November 17, 2020: “The Development of a Novel Nanobody Therapeutic for SARS-CoV-2,” Gang Ye, Joseph P. Gallant, Christopher Massey, Ke Shi, Wanbo Tai, Jian Zheng, Abby E. Odle, Molly A. Vickers, Jian Shang, Yushun Wan, Aleksandra Drelich, Kempaiah R. Kempaiah, Vivian Tat, Stanley Perlman, Lanying Du, Chien-Te Tseng, Hideki Aihara, Aaron M. LeBeau, Fang Li, BioRXivDOI: 10.1101/2020.11.17.386532v1 / NE-CAT 24-ID

November 13, 2020: “Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2,” S.A. Clark, L.E. Clark, J. Pan, A. Coscia, L.G.A. McKay, S. Shankar, R.I. Johnson, A. Griffiths, and J. Abraham, BioRXiv. DOI: 10.1101/2020.11.13.381533 / NE-CAT 24-ID-E and 24-ID-C

November 6, 2020: "Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago", Min Qiang, Peixiang Ma, Yu Li, Hejun Liu, Adam Harding, Chenyu Min, Lili Liu, Meng Yuan, Qun Ji, Pingdong Tao, Xiaojie Shi, Zhean Li, Fulian Wang, Yu Zhang, Nicholas C. Wu, Chang-Chun D. Lee, Xueyong Zhu, Javier Gilbert-Jaramillo, Abhishek Saxena, Xingxu Huang, Hou Wang, William James, Raymond A. Dwek, Ian A. Wilson, Guang Yang, and Richard A. Lerner, BioRXiv. DOI: 10.1101/2020.11.06.370676 / GMCA-XSD 23-ID-B

October 28, 2020: "The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase", Yousef M.O. Alhammad, Maithri M. Kashipathy, Anuradha Roy, Jean-Philippe Gagné, Peter McDonald, Philip Gao, Louis Nonfoux, Kevin P. Battaile, David K. Johnson, Erik D. Holmstrom, Guy G. Poirier, Scott Lovell, and Anthony R. Fehr, BioRXiv. DOI: 10.1101/2020.05.11.089375 / IMCA-CAT 17-ID

October 16, 2020: "Multivalency transforms SARS-CoV-2 antibodies into broad and ultrapotent neutralizers", Edurne Rujas, Iga Kucharska, Yong Zi Tan, Samir Benlekbir, Hong Cui, Tiantian Zhao, Gregory A. Wasney, Patrick Budylowski, Furkan Guvenc, Jocelyn C. Newton, Taylor Sicard, Anthony Semesi, Krithika Muthuraman, Amy Nouanesengsy, Katherine Prieto, Stephanie A. Bueler, Sawsan Youssef, Sindy Liao-Chan, Jacob Glanville, Natasha Christie-Holmes, Samira Mubareka, Scott D. Gray-Owen, John L. Rubinstein, Bebhinn Treanor, and Jean-Philippe Julien, BioRXiv. DOI: 10.1101/2020.10.15.341636 / GMCA-XDS 23-ID-D

October 9, 2020: "LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection", Bryan E. Jones, Patricia L. Brown-Augsburger, Kizzmekia S. Corbett, Kathryn Westendorf, Julian Davies, Thomas P. Cujec, Christopher M. Wiethoff, Jamie L. Blackbourne, Beverly A. Heinz, Denisa Foster, Richard E. Higgs, Deepa Balasubramaniam, Lingshu Wang, Roza Bidshahri, Lucas Kraft, Yuri Hwang, Stefanie Žentelis, Kevin R. Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Samuel J. Hinshaw, Sean A. Tycho, Davide Pellacani, Ping Xiang, Krithika Muthuraman, Solmaz Sobhanifar, Marissa H. Piper, Franz J. Triana, Jorg Hendle, Anna Pustilnik, Andrew C. Adams, Shawn J. Berens, Ralph S. Baric, David R. Martinez, Robert W. Cross, Thomas W. Geisbert, Viktoriya Borisevich, Olubukola Abiona, Hayley M. Belli, Maren de Vries, Adil Mohamed, Meike Dittmann, Marie Samanovic, Mark J. Mulligan, Jory A. Goldsmith, Ching-Lin Hsieh, Nicole V. Johnson, Daniel Wrapp, Jason S. McLellan, Bryan C. Barnhart, Barney S. Graham, John R. Mascola, Carl L. Hansen, and Ester Falconer, BioRXiv. DOI: 10.1101/2020.09.30.318972 / LRL-CAT 31-ID

September 8, 2020: "Structural characterization of Nonstructural protein 1 from SARS-CoV-2", Cameron Semper, Nobuhiko Watanabe, Alexei Savchenko, BioRXiv. DOI: 10.1101/2020.09.08.288191 / SBC-XSD 19-ID-D

September 1, 2020: "Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro", Nir Drayman, Krysten A. Jones, Saara-Anne Azizi, Heather M. Froggatt, Kemin Tan, Natalia Ivanovna Maltseva, Siquan Chen, Vlad Nicolaescu, Steve Dvorkin, Kevin Furlong, Rahul S. Kathayat, Mason R. Firpo, Vincent Mastrodomenico, Emily A. Bruce, Madaline M. Schmidt, Robert Jedrzejczak, Miguel Á. Muñoz-Alía, Brooke Schuster, Vishnu Nair, Jason W. Botten, Christopher B. Brooke, Susan C. Baker, Bryan C. Mounce, Nicholas S. Heaton, Bryan C. Dickinson, Andrzej Jaochimiak, Glenn Randall, and Savaş Tay, BioRXiv. DOI: 10.1101/2020.08.31.274639 / SBC-XSD 19-ID-D

September 1, 2020: "Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3", Rajdeep S. Virdi, Robert V. Bavisotto, Nicholas C. Hopper, Nemanja Vuksanovic, Trevor R. Melkonian, Nicholas R. Silvaggi, David N. Frick, BioRXiv. DOI: 10.1101/2020.07.06.190413 / LS-CAT 21-ID-F

August 16, 2020: "Methylation of RNA Cap in SARS-CoV-2 captured by serial crystallography", M. Wilamowski, D. A. Sherrell, G. Minasov, Y. Kim, L. Shuvalova, A. Lavens, R. Chard, N. Maltseva, R. Jedrzejczak, M. Rosas-Lemus, N. Saint, I.T. Foster, K. Michalska, K.J.F. Satchell, and A. Joachimiak, BioRXiv. DOI: 10.1101/2020.08.14.251421 / SBC-XSD 19-ID-D

July 23, 2020: "Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy", Ivan G. Shabalin, Mateusz P. Czub, Karolina A. Majorek, Dariusz Brzezinski, Marek Grabowski, David R. Cooper, Mateusz Panasiuk, Maksymilian Chruszcz, and Wladek Minor, BioRXiv. DOI: 10.1101/2020.07.21.212704 / LS-CAT 21-ID-F

April 26, 2020: "The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine", Monica Rosas-Lemus, George Minasov, Ludmilla Shuvalova, Nicole L. Inniss, Olga Kiryukhina, Grant Wiersum, Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Michael Endres, Lukasz Jaroszewski, Adam Godzik, Andrzej Joachimiak, and Karla J. F. Satchell, BioRXiv. DOI: 10.1101/2020.04.17.047498 / SBC-XSD 19-ID-D

March 17, 2020: "A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein", M. Gordon Joyce, Rajeshwer S. Sankhala, Wei-Hung Chen, Misook Choe, Hongjun Bai, Agnes Hajduczki, Lianying Yan, Spencer L. Sterling, Caroline E. Peterson, Ethan C. Green, Clayton Smith, Natalia de Val, Mihret Amare, Paul Scott, Eric D. Laing, Christopher C. Broder, Morgane Rolland, Nelson L. Michael, and Kayvon Modjarrad, BioRXiv. DOI: 10.1101/2020.03.15.992883 / NE-CAT 24-ID-C and NE-CAT 24-ID-E

SARS CoV-2 Research Highlights on the APS Web Site

"Mapping the Structure of a Potent Antibody against the Coronavirus" 10.28.2020

"Viral 'Molecular Scissor' is Next COVID-19 Drug Target" 10.27.2020

"How SARS-CoV-2 RNA Evades Host Immune Responses" 08.26.2020

"3-D Structure of SARS-CoV-2 Explains High Infectivity vs. Other Coronaviruses" 06.10.2020

"New Coronavirus Protein Reveals Drug Target" 03.02.2020

SARS CoV-2 Feature Articles on the Argonne Web Site

Caught in the act: New data about COVID-19 virus’s functions could aid in treatment designs

Why the lovable llama might be a secret weapon against COVID-19

APS plays foundational role in development of COVID-19 vaccines

100th structure of COVID-19 virus from Advanced Photon Source data released

Hide and seek: Understanding how COVID-19 evades detection in a human cell

World’s X-ray facilities team up to battle COVID-19

10 ways Argonne science is combatting COVID-19

Eight ways Argonne advanced science in 2020

Advanced Photon Source at the heart of COVID-19 research

How scientists around the country are using the APS to fight COVID-19

Argonne’s researchers and facilities playing a key role in the fight against COVID-19

Structural overlay of the SARS‐CoV‐2 N2b dimer (blue) and the equivalent domain of SARS‐CoV‐N (PDB ID 2CJR). From Q. Ye et al., Protein Science. DOI: 10.1002/pro.3909 © 2020 The Protein Society / NE-CAT beamline 24-ID‐E

04.16.2021