The Advanced Photon Source
a U.S. Department of Energy Office of Science User Facility

Protein Structure May Lead to Treatment for Infection Targeting Cystic Fibrosis Patients


Researchers using the Structural Biology Center 19-ID beamline at the APS have determined the structure of a key protein believed to play a role in a deadly infection that afflicts the lungs of patients with cystic fibrosis. This finding may lead to a new drug to treat the bacterial infection.

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See: J.D. Mouguos et al., "A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein Secretion Apparatus," Science 312(5779), 1526 (2006). doi: 10.1126/science. 1128393

This work was supported in part by grants from the NIH and the U.S. Department of Energy, Office of Biological and Environmental Research, under contract W-31-109-Eng-38and by the Damon Runyon Cancer Research Foundation.Use of the Advanced Photon Source was supported by the U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. W-31-109-ENG-38

Argonne National Laboratory is a U.S. Department of Energy laboratory managed by The University of Chicago

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